Categories: Letters to the Editor, Opinion A most wonderful production was put on recently at the Blue Roses Theatre in Schenectady High School. Using the words of people who actually spoke them, the play brought the audience back 25 years ago. It relived the accidental killing of a child and a rift between the black and Hassidic communities in the surrounding area of Crown Heights, Brooklyn.The theater has consistently had excellent productions and is a real gem in our community. For a top admission price of $6 ($3 for seniors and students), it can’t be topped for a marvelous afternoon or evening of good drama, comedy or a musical.Their next production will be The Addams Family in March. Take the family and see something exciting. These young people deserve to be supported.Sally MadgidNiskayunaMore from The Daily Gazette:Foss: Should main downtown branch of the Schenectady County Public Library reopen?Puccioni’s two goals help Niskayuna boys’ soccer top Shaker, remain perfectEDITORIAL: Beware of voter intimidationNiskayuna girls’ cross country wins over BethlehemEDITORIAL: Thruway tax unfair to working motorists
The modified common cold viruses behind high-profile COVID-19 vaccine candidates from China’s CanSino Biologics and Russia’s Gamaleya Institute have been studied for decades, but are still not widely used.The following are some details of their development, how they work and past and potential future uses: When were these viruses first used in medical research? Vectors are materials used as mechanisms to carry genetic information into human cells. Modified viruses that cannot replicate on their own and so will not cause infection can be used as vectors to carry genes from the target virus into human cells to induce an immune response against that virus.Ad5 vectors were tested in early gene therapy, which aims to install a missing gene or replace a mutated or damaged one. They were largely abandoned after an 18-year-old died in 1999 from an immune system overreaction after receiving a large dose during a gene therapy trial.Some researchers believe the strong immune response that caused problems with gene therapy makes these vectors well suited to vaccines, where much lower doses are used and a protective immune response is the objective.Have ad5 vectors been successful in the past?At McMaster University in Canada, Graham and collaborators developed a variety of Ad5 vectors, including for a rabies vaccine used on wild raccoons in the province of Ontario.He and other researchers began developing an Ad5-based vaccine against Severe Acute Respiratory Syndrome (SARS) in 2003 and published preclinical data. It was set aside when that pandemic ended.In 2011, CanSino licensed an experimental tuberculosis vaccine based on Ad5 from McMaster researchers.The Chinese company’s focus later shifted to an Ad5-based Ebola vaccine at the request of the Chinese military, according to Dr. Thomas Evans, current chief scientific officer at Vaccitech, who was involved with the tuberculosis project. The Ebola vaccine was approved for military use in 2017.Russia’s Gamaleya Research Institute, which developed Russia’s coronavirus vaccine, also used the Ad5 platform to develop an Ebola vaccine, which they said has been administered to about 2,100 people.What else is under development using ad5 vectors?In addition to the Ad5-based COVID-19 vaccines, an inhaled version of the experimental tuberculosis vaccine is still under development at McMaster, Dr. Zhou Xing told Reuters. His team is also in the early stages of developing an inhaled COVID-19 vaccine, testing Ad5 and another vector based on a chimpanzee adenovirus. Topics : The modified adenovirus type 5 (Ad5) viruses used in these vaccines grow in a human kidney cell line called HEK293 that was created by Canadian researcher Dr. Frank Graham at a Dutch lab in the 1970s and first used to make viral vectors in the 1980s.Graham planned to use HEK293 cells to study mechanisms underlying cancer, and distributed them to researchers all over the world.”The cells became tremendously widespread and popular” among researchers, said Graham, now retired in Italy.What are vectors used in vaccines and how do they work?
May 12, 2016 SHARE Email Facebook Twitter Press Release, Zika Harrisburg, PA – Pennsylvania Governor Tom Wolf today announced his administration’s plan to bolster surveillance, mitigation, and response efforts for Zika virus to better protect all residents in the commonwealth.The Pennsylvania Zika Virus Response Plan, developed by the Pennsylvania Departments of Health and Environmental Protection, outlines the phases of education, surveillance, and response activities that will occur for various levels of mosquito activity within the commonwealth as well as triggers based on the presence of Zika disease within our state. The phases range from the current situation of a moderate level of travel-associated cases to potential widespread local transmission by mosquitos. Pennsylvania has requested funds from the Centers for Disease Control and Prevention (CDC) to implement this plan.“My administration is committed to ensuring the health and safety of all Pennsylvanians,” said Governor Wolf. “We are continuing to work with our partners on the local, state, and federal levels to keep Pennsylvania safe. The roll-out of this plan is another proactive step in our collaborative strategy to protect our citizens and prevent the spread of the Zika virus.”“This Zika Virus Response Plan will better help us protect the health of the more than 12 million people who call Pennsylvania home,” said Secretary of Health Karen Murphy. “Zika generally causes very mild symptoms and rarely leads to serious side effects in those who become ill with the virus. However, pregnant women and those of childbearing age are at greatest risk as Zika is known to potentially cause serious and even fatal birth defects in some babies born to women infected with the virus during pregnancy. This plan will help ensure we have the measures in place to better inform and protect all of our residents.”The main goals of the Pennsylvania Zika Virus Response Plan are to:Enhance DOH surveillance for Zika cases in Pennsylvanians;Develop a plan that will enable DOH to test for the virus without using CDC laboratories;Enhance DEP vector surveillance and control of the Aedes albopictus and Aedes aegypti species of mosquitos; andEnsure collaboration between commonwealth agencies and partners to educate pregnant women and the general public about important Zika virus messages.Currently, the only confirmed cases of Zika in Pennsylvania are in individuals who contracted the virus while visiting one of the areas where the virus is actively spreading. At this time, no cases of Zika in Pennsylvania or in the continental U.S. have occurred as a result of locally acquired infections. Once warmer temperatures arrive in the commonwealth and remain in place throughout the summer months, the risk of limited local transmission of Zika virus by the type of mosquitos that potentially carry it will increase.“DEP and our county partners are focused on monitoring for the presence of mosquitos potentially associated with Zika transmission and implementing control measures when necessary,” said DEP Secretary John Quigley. “We are working very closely with the Department of Health to ensure the safety of our citizens.”Zika is a generally mild illness, and most individuals do not have any symptoms. When symptoms do occur, they can include fever, rash, joint or muscle pain, conjunctivitis (pink eye), or headache, and last from several days to one week.Although the Aedes aegypti mosquito remains the primary carrier of the Zika virus, Aedes albopictus has also been implicated as a secondary carrier of this disease. While Aedes aegypti has not been found in Pennsylvania since 2002, Aedes albopictus has been found throughout the major metropolitan areas of southern Pennsylvania. These species are different from ones DEP currently surveys and require different tactics. The new surveillance and control methods outlined in the plan that are needed to protect public health from this potential threat will require additional DEP resources.The disease can also be transmitted sexually, as well as by blood transfusions. The CDC advises men who have traveled to the Zika-affected areas to wear condoms consistently and correctly during sex to avoid spreading the virus to their partners. This is especially important for men whose partners are pregnant women or women who are of childbearing age, as the Zika virus has been linked to potentially severe birth defects in babies born to women who had the illness during pregnancy.The CDC also recommends that all pregnant women consider postponing travel to Zika-affected areas. Women who are pregnant, planning to become pregnant, or may be pregnant and must travel to these areas should first consult with their health care provider. Pregnant women who visit Zika-affected areas and develop symptoms within two weeks of returning home should contact their health care provider.Because there currently is no vaccine or treatment for Zika, the best way to avoid contracting the virus is to prevent mosquito bites by:Using an insect repellent containing DEET;Wearing light-colored, lightweight, loose-fitting clothing that covers hands, arms, legs, and other exposed skin.Using physical barriers such as screens, closed doors and windows.The Aedes types of mosquitos that can potentially transmit the Zika virus bite during the daytime. To control all mosquitos outside your home or business:Install or repair and use window and door screens.Once a week, empty and scrub, turn over, cover, or throw out any items that hold water like buckets, planters, toys, pools, birdbaths, flowerpot saucers, or trash containers. Mosquitos lay eggs near water. Use an outdoor flying insect spray where mosquitos rest – dark, humid areas like under patio furniture or under the carport or garage.Have clogged roof gutters cleaned every year, particularly if the leaves from surrounding trees have a tendency to plug up the drains. Roof gutters can produce millions of mosquitoes each season.If you have a septic tank, repair cracks or gaps. Cover open vent or plumbing pipes with wire mesh that consists of holes smaller than an adult mosquito.For more information, visit www.zika.pa.gov.Like Governor Tom Wolf on Facebook: Facebook.com/GovernorWolf Wolf Administration Increases Zika Surveillance Plans; Risk of Contracting Virus in Commonwealth Currently Very Low
John McGrath is predicting the Gold Coast will continue to benefit (from growth) over the next five years.LEADING real estate industry figure John McGrath is tipping the Gold Coast property market to benefit from the 2018 Commonwealth Games for the next five years.“Having experienced Sydney in 2000 with the Olympics and knowing what the Gold Coast has to offer, I can only say the Commonwealth Games will be an amazing postcard to the world,” Mr McGrath said.“You’ve got the fact the whole world will be exposed to an incredible city and lifestyle, as well as the fact the infrastructure investment in the lead-up has been prolific and the market is so undervalued.“I think the Gold Coast will continue to benefit (from growth) over the next five years.”More from news02:37Purchasers snap up every residence in the $40 million Siarn Palm Beach North2 hours ago02:37International architect Desmond Brooks selling luxury beach villa22 hours agoVideo Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 3:46Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -3:46 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD540p540p360p360p270p270pAutoA, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenGrowth of regional hubs03:46Mr McGrath’s top suburb pick on the Gold Coast in his McGrath Report 2018, released on the weekend was Coomera.WHY COOMERA IS SET TO BOOMHe said Coomera would benefit from new infrastructure including the $470 million Westfield Shopping Centre which is expected to open in late 2018.“There are a lot of great areas in between Brisbane and the Gold Coast and Coomera is a great example,” Mr McGrath said.“I think it will continue to grow.”
THE GOVERNMENT of Kazakstan has approved a comprehensive upgrading plan for the republic’s railways, including new lines to integrate the former SZD West Kazakstan and Almaty regional railways.Top priority in the package are measures to cut the use of imported diesel fuel, which currently accounts for 80% of KR’s operating costs. Wiring of the Almaty – Chu line is due to be completed by the end of 1998, providing an electrified trunk network linking the old capital with its sucessor Akmola, the western city of Kustanai and the Uzbekistan capital Tashkent.Three new cut-offs have been authorised. The links from Djenkazgan to Kyzil-Orda and Chelkar to Beinei will create a new corridor to the southwest, cutting diesel fuel usage by around 10%. South Korean contractors will participate in construction of the Djenkazgan – Kyzil-Orda line. In the northwest, a link from Zhangiz-T
Susan Lee Robinson, 74, of Metamora, IN passed away Wednesday morning, April 20, 2016 at Brookville Healthcare Center where she had been a resident since September 23, 2015. She had been in failing health for the past several months.She was born November 11, 1941 in Cincinnati, OH, the daughter of John Carl and Mary Guisinger Hibbett.On May 7, 1988, she was married in the Elm Grove Baptist Church in Metamora, IN to Raymond Lee Robinson. She was a loving and devoted wife, mother, grandmother and homemaker. Mr. Robinson survives.She was a faithful member of the Elm Grove Baptist Church, Metamora, IN. In her leisure she enjoyed bird watching, working in her flower and vegetable garden and was an avid adult softball player, playing for the women’s softball team, “The Ding-A-Lings”.Survivors include her husband, Raymond Robinson, of Metamora, IN; three children, Michael Anthony Panzeca, of Pompano Beach, FL, John Dominic Panzeca and wife, Susan, of Milford, OH and Gina Marie Panzeca, of Reading, OH; two step-daughters, Deborah Jean Spurlock, of Connersville and Angela Kay Ruble, of Laurel; seven grandchildren, Brett Andrew Frosio, Benjamin John Panzeca, Bethany Rose Panzeca, April Renee Baker, Regina Michelle Ault, Amanda Pauline Allen and Trevor Lee Ruble; seven great-grandchildren, Harleigh Johnson, Eli Ault, Abryann Baker, Owen Baker, Luke Baker, Lilly Baker and Mason Allen; a brother, Jim Minshall, of Cincinnati, OH; two sisters, Judy Smith, of Palm Beach Gardens, FL and Barbara “Bobbie” Schmidt, Cincinnati, OH; a number of nieces, nephews and cousins.She is preceded in death by her parents and a brother, Bill Hibbett.Funeral services will be held at 1 PM, Monday, April 25, 2016 at Miller, Moster, Robbins Funeral Home with Pastor Randy Edwards officiating. Burial will be in Laurel North Cemetery. Friends may call at the funeral home from 11 AM until 1 PM on Monday and anytime at millermosterrobbins.com.
Yet Mourinho knows improvement is required if Chelsea are to prevail under a renewed challenge from Manchester City, Arsenal, Manchester United and Liverpool next season. “We have to be better if we want to be successful again,” Mourinho told Chelsea TV. “The other opponents are not going to accept this without a fight.” It was Mourinho’s third Premier League title and first of his second spell. “Next year will be more difficult, but because it’s difficult is one of the reasons why I came back to England. I will enjoy it again,” he added. Captain John Terry claimed his fourth Premier League title and first since 2009/10. “It’s been a long five years,” said the 34-year-old, who signed a 12-month contract extension in March. “When you get to my age you realise these moments and these days won’t be around forever. Chelsea manager Jose Mourinho has told his Premier League-winning side they must be even better next season to retain the trophy. “Let’s make sure it’s not another five before we win it again.” Didier Drogba won a fourth title before bidding farewell. The 37-year-old was carried from the pitch by his team-mates in a pre-planned first-half substitution as his season-long second spell ended. Terry hopes Frank Lampard will one day receive the type of send off given to Drogba, who scored the decisive penalty in the 2012 Champions League win before departing the first time. Lampard left English football for Major League Soccer after spending the season at Manchester City, following the end of his 13-year stay at Stamford Bridge last summer. “I hope one day Lamps can come back and get that send off,” Terry added. “What they achieved day-in, day-out, year after year, was an example to everyone. “They’ve set the base and the foundation for everyone to build upon. “What amazes me with those two (is) they’ve won everything and still the next season they’re hungry to win more. That’s why they’re the best.” It may have been goalkeeper Petr Cech’s final appearance, too. The 33-year-old, displaced as first choice by Thibaut Courtois after a decade as number one, is expected to ask for a move this summer, despite having one year left on his contract. Whether a move to rival clubs United and Arsenal, who are reportedly among those interested, is sanctioned remains to be seen. Cech made no mention of his future after the Sunderland clash. “It’s been a great year. We won two trophies,” he said. “This league is the best league in the world and you have great teams following you, trying to shoot you down from first spot. “We managed to stay there the whole year and are worthy champions.” Terry played every minute of every Premier League game, becoming the first outfield player to do so for a championship-winning side since Manchester United’s Gary Pallister in 1992/93. “Let’s hope I can stay for a long time and be part of this great team,” Terry added. Drogba, meanwhile, departs. “I was coming back to make history and to win. I came back for it and we achieved it together, so I’m very happy,” he said. Asked by team-mate John Obi Mikel when he will return, Drogba said: “My friend, legends always come back.” The Blues suffered only three defeats all season before lifting the trophy after Sunday’s concluding 3-1 defeat of Sunderland at Stamford Bridge. Mourinho’s men topped the table for 274 days, a Premier League record, having only briefly been knocked off top spot on goal difference by Tottenham at the end of August. Press Association
No. 3 Oregon routs Utah in Pac 12 quarterfinals, 79-57 March 6, 2020 Associated Press Satou Sabally added 17 points, while Jaz Shelley chipped in with 10 for the top seed in the tournament.Utah, which has been led by underclassmen all season, including in its 72-63 opening-round win over Washington, was paced by freshmen Lola Pendande and Brynna Maxwell, who finished with 15 and 12 points, respectivelyOregon, which swept the regular-season series by a combined 64 points, shot 29 of 58 (50%) for the game. The Ducks were 12 of 23 from 3-point range, falling one 3-pointer shy of tying the Pac-12 Tournament single-game record.With a third straight Pac-12 regular-season title in hand, the Ducks will ride a 17-game winning streak into their fourth successive Pac-12 Tournament semifinal, where they’ll meet Arizona, a 73-86 winner over Cal in an earlier quarterfinal.Oregon, which has played for the last two Pac-12 championships, is looking for its second conference tournament title after winning in 2017-18. Stanford defeated the Ducks in last year’s title game. Share This StoryFacebookTwitteremailPrintLinkedinRedditLAS VEGAS (AP) — Sabrina Ionescu scored 19 points to lead No. 3 Oregon to a 79-59 victory over Utah in the Pac-12 quarterfinals on Friday afternoon.The Ducks erased a six-point first-quarter deficit and used a 20-4 run in the second quarter to seize momentum. Igniting the run was a 3-point barrage, which saw Oregon (29-2) connect on eight consecutive shots from beyond the arc to close the half.Oregon shot 10 of 16 from the floor in the second quarter, including 8 of 12 from 3-point range, while limiting the Utes (14-17) to a bleak 18.8% (3 of 16) shooting. BIG PICTUREUtah: The Utes’ underclassmen accounted for 73% of the team’s offensive production this season, including 42% from their three freshmen: Maxwell, Pendande and Kemery Martin. In all, there are eight underclassmen on Utah’s roster, making the future bright for coach Lynne Roberts’ group.Oregon: Shelley, just a freshman, continues to impress off the bench, as she now has six double-figure scoring games. The Australian is a Pac-12 all-freshman honorable mention after averaging 6.3 points per game. Shelley broke Oregon’s single-game record for 3-pointers in the 10th game of her college career when she went 10 for 14 from deep in a 32-point performance against UC Riverside on Dec. 16.UP NEXTUtah: Utes season comes to an end. Oregon: Will play Arizona in Saturday’s semifinals.___ More AP women’s basketball: https://apnews.com/Womenscollegebasketball and https://twitter.com/AP_Top25
Naomi Cowan (second left) at Kanye West’s October 18 Sunday Service concert at Emancipation Park in Kingston. From left is Jesse Royal, Carlene Davis, Jamaica’s Entertainment and Culture minister Olivia Grange, Kanye West and Tommy Cowan. KINGSTON, Jamaica – Hours before she headed to Emancipation Park in Kingston with her family for Kanye West’s Sunday Service show on October 18, singer Naomi Cowan heard of a shooting incident near her office, a five-minute walk from the venue.By that evening, her concern had given way to hope as she was in the massive crowd that watched the rapper and his gospel group turn in a mesmerizing performance.It was enough to wash her blues away.“All he’s doing is telling people to be fearless, telling them how to be creative,” said Cowan. “He was using contemporary sounds and R&B riffs but the message was so strong you could not help but be a part of it,” Cowan said.Cowan was accompanied to the event by her parents, veteran artist manager/producer Tommy Cowan and his wife, singer Carlene Davis. Several Jamaican gospel singers also attended, as did Jesse Royal, a key figure in the roots-reggae revival and the country’s entertainment and culture minister, Olivia “Babsy” Grange.The Kingston show was a pop up gig for the controversial West who recently embraced Christianity. He is currently promoting Jesus is King, his first gospel album, released in October.Cowan has done a handful of gospel songs but made her mark in 2018 with Paradise Plum, a catchy dance track that did well on regional charts in the United States.While her day started ominously, she credited West and his Sunday Service singers for making it worthwhile in the end.“I had a fantastic time and I’m so full of gratitude. I really was on Cloud Nine and so thankful for life,” she said.West has held several Sunday Service shows in the US since its launch in January. His Jamaican leg was not without incident, as Grange issued a statement ordering the rapper to stop selling merchandise bearing Jamaica’s national emblem.